<16> Polyphenols inhibit Hepatitis C virus entry by a new mechanism of action
Polyphenols
Inhibit Hepatitis C Virus Entry by a
New Mechanism of Action
Noémie
Calland1, Marie-Emmanuelle Sahuc, Sandrine Belouzard ,
Véronique Pène, Pierre Bonnafous, Ahmed Atef Mesalam , Gaspard Deloison, Véronique Descamps , Sevser Sahpaz , Czeslaw Wychowski , Olivier Lambert , Priscille
Brodin, Gilles Duverlie ,
Philip Meuleman, Arielle R. Rosenberg , Jean Dubuisson, Yves Rouillé , and
Karin Séron
Journal of Virology. 2015 July 22. 10.1128:01473-15
Speaker: Sina Taheri (白明旭) Time:14:10~15:00,
Oct.21
Commentator: Dr. Kung-Chia Young (楊孔嘉 老師) Place: Room 601
Abstract:
Hepatitis C is a
major health problem with as many as 130 million people chronically infected
worldwide [1]. It is caused by hepatitis C virus (HCV), which has a high
propensity to establish a persistent infection. Chronic hepatitis C can lead to
the development of cirrhosis and hepatocellular carcinoma. Despite the validation
of direct acting antivirals for hepatitis C treatment, discovery of new
compounds with different modes of action may still be of importance for the
treatment of special patient populations.
The
science recently identified a polyphenol, Delphinidin
as an inhibitor of hepatitis C virus (HCV) targeting the viral particle. This natural compound, a plant pigment responsible
for the blue purple color of flowers and berries, belongs to the flavonoid
family, like the catechin EGCG, the major component
present in green tea extract, which is also an inhibitor of HCV entry. Studied the mode
of action of this compounds against HCV and demonstrated that he act directly
on the virus, inducing a bulging of the viral envelope. This deformation might
be responsible for the inhibition of the virus attachment to the cell surface.
The discovery of such anti-HCV inhibitors with an unusual mode of action is
important to better characterize the mechanism of HCV entry into hepatocyte and
to help developing a new class of anti-HCV entry inhibitors. HCV JFH1 in cell
culture and HCV pseudoparticle systems were used to
determine antiviral activity and mechanism of action of the compounds. We
identified delphinidin, a polyphenol belonging to the
anthocyanidin family, as a new inhibitor of HCV
entry. Delphinidin inhibits HCV entry, in a
pan-genotypic manner, by acting directly on the viral particle and impairing
its attachment to the cell surface.
References:
1. Lavanchy D. 2011. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect 17:107-115.
2. Colpitts CC, Schang LM.